Structural Basis for Enzyme I Inhibition by α-Ketoglutarate
                    
                        
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                    چکیده
منابع مشابه
Structural basis for enzyme I inhibition by α-ketoglutarate.
Creating new bacterial strains in which carbon and nitrogen metabolism are uncoupled is potentially very useful for optimizing yields of microbial produced chemicals from renewable carbon sources. However, the mechanisms that balance carbon and nitrogen consumption in bacteria are poorly understood. Recently, α-ketoglutarate (αKG), the carbon substrate for ammonia assimilation, has been observe...
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The aquaporin family of channels was defined based on the inhibition of water transport by mercurial compounds. Despite the important role of mercurials, little is known about the structural changes involved upon mercury binding leading to channel inhibition. To elucidate the mechanism we designed a mutant, T183C, of aquaporin Z (AqpZ) patterned after the known mercury-sensitive site of aquapor...
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ژورنال
عنوان ژورنال: ACS Chemical Biology
سال: 2013
ISSN: 1554-8929,1554-8937
DOI: 10.1021/cb400027q